Liposclerosing myxofibrous tumor: a series of 9 cases and review of the literature

Abstract

Objective: Liposclerosing myxofibrous primary bone tumor is a rare benign bone lesion that was characterized by complex mixture of various histological elements.

Methods: We have studied the radiological, clinical and pathological features of nine patients with this disorder. Pain and limping were the main symptoms.

Results: Radiographic images typically showed a geographic lytic lesion with thick sclerotic margin, reflecting a pattern of slow growth. Histological sections revealed a polymorphic neoplasia characterized by predominant proliferation of stellate and fusiform cells aimed the myxoid matrix.

Conclusions: These features suggest that the lesion may represent a variant of fibrous dysplasia with a high risk of malignant transformation.