New strategy to control cell migration and metastasis regulated by CCN2/CTGF

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dc.contributor.authorAguiar, Diego Pinheiro
dc.contributor.authorFarias, Gabriel Correa de
dc.contributor.authorSousa, Eduardo Branco de
dc.contributor.authorAguiar, Juliana de Mattos Coelho
dc.contributor.authorLobo, Julie Calixto
dc.contributor.authorCasado, Priscila Ladeira
dc.contributor.authorDuarte, Maria Eugênia Leite
dc.contributor.authorAbreu Junior, José Garcia Ribeiro
dc.date.accessioned2026-09-03T18:36:51Z
dc.date.issued2014
dc.description.abstractObjective: Connective tissue growth factor (CTGF)/CCN family member 2 (CCN2) is a CCN family member of matricellular signaling modulators. It has been shown that CCN2/CTGF mediates cell adhesion, aggregation and migration in a large variety of cell types, including vascular endothelial cells, fibroblasts, epithelial cells, aortic smooth muscle and also pluripotent stem cells. Others matricellular proteins are capable of interacting with CCN2/CTGF to mediate its function. Cell migration is a key feature for tumor cell invasion and metastasis. CCN2/CTGF seems to be a prognostic marker for cancer. In addition, here we intend to discuss recent discoveries and a new strategy to develop therapies against CCN2/CTGF, in order to treat cancer metastasis.
dc.identifier.citationAGUIAR, Diego Pinheiro; FARIAS, Gabriel Correa de; SOUSA, Eduardo Branco de; AGUIAR, Juliana de Mattos Coelho; LOBO, Julie Calixto; CASADO, Priscila Ladeira; DUARTE, Maria Eugênia Leite; ABREU JUNIOR, José Garcia Ribeiro. New strategy to control cell migration and metastasis regulated by CCN2/CTGF. Cancer Cell International. United Kingdom. v.14. n. 61. p1-7. 2014.
dc.identifier.doi10.1186/1475-2867-14-61
dc.identifier.issn1475-2867
dc.identifier.urihttps://ortobase.into.saude.gov.br/handle/123456789/774
dc.language.isoen
dc.publisherCancer Cell International
dc.subjectCCN2
dc.subjectCTGF
dc.subjectAdhesion
dc.subjectMigration and Metastasis
dc.titleNew strategy to control cell migration and metastasis regulated by CCN2/CTGF
dc.typeArticle

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