Evaluation of BCL-2, BCL-X and cleaved caspase-3 in malignant peripheral nerve sheath tumors and neurofibromas

Simple item page
dc.contributor.authorCunha, Karin Soares
dc.contributor.authorCaruso, Anabela C.
dc.contributor.authorFaria, Paulo A.
dc.contributor.authorSilva, Licínio E. da
dc.contributor.authorFonseca, Eliene C. da
dc.contributor.authorGeller, Mauro
dc.contributor.authorNeto, Rodrigo S. de Moura
dc.contributor.authorLopes, Vânia S.
dc.date.accessioned2026-01-16T15:38:35Z
dc.date.issued2013
dc.description.abstractObjective: To study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated. MATERIALS AND METHODS: The evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis. CONCLUSIONS: Apoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.
dc.identifier.citationCUNHA, Karin S.; CARUSO, Anabela C.; FARIA, Paulo A.; SILVA, Licínio E. da; FONSECA, Eliene C. da; GELLER, Mauro; NETO, Rodrigo S. de Moura; LOPES, Vânia S. Evaluation of BCL-2, BCL-X and cleaved caspase-3 in malignant peripheral nerve sheath tumors and neurofibromas. Anais da Academia Brasileira de Ciências. Rio de Janeiro. v.85. S4. p1-15. 2013 DOI http://dx.doi.org/10.1590/0001-3765201320120026
dc.identifier.issn1678-2690
dc.identifier.urihttps://ortobase.into.saude.gov.br/handle/123456789/411
dc.language.isoen
dc.publisherAnais da Academia Brasileira de Ciências
dc.subjectApoptosis Regulatory Proteins
dc.subjectMalignant Peripheral Nervous Sheath Tumors
dc.subjectNeurofibroma
dc.subjectNeurofibromatosis 1
dc.titleEvaluation of BCL-2, BCL-X and cleaved caspase-3 in malignant peripheral nerve sheath tumors and neurofibromas
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Cunha, Karin S. et al_2013.pdf
Size:
1.46 MB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download

Collections

Artigos Científicos